Explore The Science Behind Rapamycin

Browse existing research summaries on rapamycin and longevity science.

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2024 Publication

mTOR & autophagy Preclinical study

A Surge In Endogenous Spermidine Is Essential For Rapamycin-Induced Autophagy And Longevity

Hofer SJ, et al. · Autophagy

Reports that rapamycin-induced autophagy and lifespan extension depend on a rise in endogenous spermidine, shown across yeast, worms, flies and mice — a mechanism-level result, not a human outcome.

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