Topic: Ageing Biology

October 1, 2014

Reviews mTOR inhibition and mammalian longevity, arguing the current evidence best fits lifespan extension mainly through cancer suppression, with symptomatic…

December 1, 2014

A randomised, observer-blind, placebo-controlled trial in 218 adults aged 65 and over reports that six weeks of low-dose RAD001 improved…

July 1, 2018

A phase 2a randomised, placebo-controlled trial in 264 adults aged 65 and over reports that six weeks of a low-dose…

March 1, 2025

A clinical review of geroscience: which ageing pathways can be modified, and how much human evidence currently supports each intervention.

May 1, 2025

An open-label phase 1 pilot trial in ten older adults with mild cognitive impairment or early Alzheimer's dementia: eight weeks…

December 1, 2025

A single-arm, open-label pilot trial in 14 people with early Alzheimer's disease: six months of weekly oral rapamycin was tolerated,…