- April 1, 2006A Spanish Society of Nephrology consensus review of how the mTOR inhibitor sirolimus is managed in transplant practice, covering its…
- April 1, 2012Reviews the overlap between ageing biology and cardiovascular disease, and why age remains the largest risk factor for cardiovascular disease.
- October 1, 2014Reviews mTOR inhibition and mammalian longevity, arguing the current evidence best fits lifespan extension mainly through cancer suppression, with symptomatic…
- January 1, 2016A review of mTOR biology and rapamycin as an anti-ageing compound argues that many of the drug's side effects are…
- August 1, 2019Argues that rapamycin, like fasting and very low-calorie diets, can raise blood glucose in a reversible form that is not…
- April 1, 2021Reviews the mouse evidence that rapamycin extends lifespan and affects age-related conditions including cardiac function, the nervous system, immunity and…
- August 1, 2023Reviews how autophagy behaves in the failing heart across ischaemic, pressure-overload, diabetic and drug-induced models, and whether pharmacologic modulators of…
- August 1, 2024A narrative review of how mTOR overactivation is proposed to link diet, salt intake and the renin-angiotensin-aldosterone system to insulin…
- March 1, 2025A clinical review of geroscience: which ageing pathways can be modified, and how much human evidence currently supports each intervention.
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