- April 1, 2006A Spanish Society of Nephrology consensus review of how the mTOR inhibitor sirolimus is managed in transplant practice, covering its…
- December 1, 2007Cell experiments show that rapamycin pushes human vascular smooth muscle cells toward a mature, contractile state by relieving S6K1-dependent inhibition…
- February 1, 2010Cell and mouse-cell experiments report that the longevity-linked deacetylase SIRT1 restrains mTOR signalling, apparently by acting through the TSC1/TSC2 brake…
- April 1, 2012A rat and cell study reports that three weeks of chronic sirolimus treatment lowered body weight and fat mass while…
- August 1, 2019Argues that rapamycin, like fasting and very low-calorie diets, can raise blood glucose in a reversible form that is not…
- August 1, 2023Reviews how autophagy behaves in the failing heart across ischaemic, pressure-overload, diabetic and drug-induced models, and whether pharmacologic modulators of…
- August 1, 2024A narrative review of how mTOR overactivation is proposed to link diet, salt intake and the renin-angiotensin-aldosterone system to insulin…
- September 1, 2024Reports that rapamycin-induced autophagy and lifespan extension depend on a rise in endogenous spermidine, shown across yeast, worms, flies and…
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