Source Type: Preclinical Study

December 1, 2007

Cell experiments show that rapamycin pushes human vascular smooth muscle cells toward a mature, contractile state by relieving S6K1-dependent inhibition…

February 1, 2010

Cell and mouse-cell experiments report that the longevity-linked deacetylase SIRT1 restrains mTOR signalling, apparently by acting through the TSC1/TSC2 brake…

April 1, 2012

A rat and cell study reports that three weeks of chronic sirolimus treatment lowered body weight and fat mass while…

August 1, 2016

In rats doing a resistance-exercise model, rapamycin fully blocked exercise-induced ribosome biogenesis but only partly reduced muscle protein synthesis and…

September 1, 2024

Reports that rapamycin-induced autophagy and lifespan extension depend on a rise in endogenous spermidine, shown across yeast, worms, flies and…