"How eating less (caloric restriction) and using Rapamycin might be related" "How both affect the same core biological pathway: the mTOR pathway" Both caloric restriction (CR) and rapamycin influence the mTOR pathway, a central regulator of growth, metabolism, and aging. mTOR stands for "mechanistic Target of Rapamycin" — the very molecule that rapamycin targets, and…

Breakthrough Drug Duo Prolongs Mouse Lifespan by 30% A pioneering study from Germany's Max Planck Institute for Biology of Aging has unveiled that a combination of two existing cancer medications—rapamycin and trametinib—can extend the lifespan of mice by approximately 30%. This discovery offers promising insights into potential anti-aging therapies for humans. The Study's Findings In…

A potential breakthrough in feline medicine is offering new hope to cat owners and veterinarians battling hypertrophic cardiomyopathy (HCM)—a leading cause of sudden death in cats. The drug rapamycin, long studied for its anti-aging properties, is now showing strong potential to prevent or even reverse the progression of HCM in cats. A Historic Milestone: FDA…

The Dog Aging Project has reached an exciting milestone in its landmark study on healthy aging in dogs. The project recently announced that the first participants—Zoe and Jack—have completed their full three-year involvement in the Test of Rapamycin in Aging Dogs (TRIAD), a groundbreaking clinical trial exploring whether the drug rapamycin can slow or mitigate…

Early results from a phase 1 clinical trial suggest that weekly administration of rapamycin may significantly improve patient-reported outcome measures (PROMs) in individuals living with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). The findings were presented by Stephanie L. Grach, MD, MS, assistant professor of medicine at Mayo Clinic, during the 2025 American College of Physicians (ACP)…

A medication once reserved for preventing organ rejection, rapamycin is now gaining momentum in the field of anti-aging science. Initially created as an immunosuppressive drug, rapamycin is now being studied for its potential to slow aging and prolong human life. With growing scientific support pointing to its possible benefits in fighting age-related illnesses, researchers are…

1. mTOR Pathway and Aging 2. Muscle Benefits 3. Exercise Synergy A clinical trial led by Dr. Brad Stanfield and Dr. Matt Kaeberlein is investigating the effects of weekly rapamycin supplementation on muscle strength and endurance in older adults. The study aims to determine if rapamycin can mitigate age-related muscle atrophy and enhance exercise outcomes.…

What is Rapamycin? Rapamycin is a drug that was originally used to prevent organ transplant rejection. It works by inhibiting a protein complex called mTOR (mechanistic Target of Rapamycin), which plays a major role in cell growth, aging, and metabolism. How Could Rapamycin Help Hair Growth? There's early evidence that mTOR inhibition may stimulate dormant…

With this article the New York Times gives good examples about how Rapamycin works for human. They explained the main idea "Rapamycin for Longevity" with doctors and reserchers words and thoughts.Lets see who said what ! Mr. Berger( who interviewed for this article) said he hasn’t experienced any “‘Oh my God, I’m a different person’…

What is Off-Label Use? Off-label drug use refers to the practice of prescribing medications for purposes other than what they were originally approved for by regulatory authorities like the FDA. While off-label use is legal and common, it typically occurs when a doctor believes that the drug may be beneficial for a particular condition based…