What is Off-Label Use?Off-label drug use refers to the practice of prescribing medications for purposes other than what they were originally approved for by regulatory authorities like the FDA. While off-label use is legal and common, it typically occurs when a doctor believes that the drug may be beneficial for a particular condition based on…

Sirolimus (also known as rapamycin) has several important uses in human medicine, particularly in transplant medicine and other areas. Here's how sirolimus can help people:1. Prevention of Organ Rejection (Immunosuppressive Therapy)Sirolimus is most commonly used in organ transplant patients to prevent organ rejection. It works by suppressing the immune system to prevent the body from…

Rapamycin has gained attention as a potential life-extending drug in humans, and there's ongoing research into its effects on pets, especially dogs. Rapamycin is an immunosuppressant that has been used for various medical conditions, including preventing organ transplant rejection and treating certain cancers. However, more recently, scientists have been exploring its potential as a longevity-promoting…

Dr. Mikhail Blagosklonny is best known for his pioneering research on aging, cancer, and the mTOR pathway, which is central to his work on rapamycin and its potential as an anti-aging and cancer therapeutic.He has written extensively about the potential of rapamycin as an anti-aging drug. His research largely focuses on the mTOR pathway, which…

Rapamycin, originally developed as an immunosuppressant, has been explored for its potential to extend lifespan and delay aging. The Guardian has reported on several studies investigating its effects:While these studies are promising, rapamycin's use as an anti-aging treatment remains experimental. Further research is necessary to fully understand its efficacy and safety in humans.

Rapamycin has been researched by many doctors and academicians and articles have been published about its benefits. As we know, in addition to supporting a long and healthy life, it is also anti-cancer, making it a very valuable supplement. Now let's look at what a few people have to say about Rapamycin.Dr. David Sinclair (Harvard…

Rapamycin and Its Anti-Aging PromiseRapamycin is a drug that doctors use to prevent the immune system from rejecting transplanted organs. Scientists discovered it in the soil of Easter Island, where certain organisms produce this molecule. Later, researchers observed that rapamycin blocks a cellular process called mTOR. This process helps regulate cell growth and repair, which…

Tumor Susceptibility Gene 101 (TSG101) plays a part in the cell’s usual controls on growth or repair, a process that helps cells clear excess proteins. Cleaning ht cell from these excess proteins is called autophagy, and it keeps neuron cells healthy.Rapamycin is a chemical that triggers autophagy. The study showed that Rapamycin increased TSG101 protein…

IntroductionDr. Joan Mannick is a medical doctor who studied how the body ages. She grew up in a family of doctors. She then chose a path in medicine, moved to research, and started looking at ways to keep people healthier as they grow older. Her work focuses on a protein called mTOR, which may help…

Rapamycin and Its Potential in Extending Human LifespanRapamycin was originally developed as an immunosuppressant to prevent organ transplant rejection and its potential applications in extending the human lifespan. Rapamycin is a geroprotective drug, that is not necessarily to benefit in one aspect, i.e. a chronic disease, but is fundamentally altering the biology of aging. Recent…